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Hesperidin is one of the bioflavinoids, naturally occurring nutrients usually
found in association with Vitamin C. Some symptoms
originally thought to be due to Vitamin C deficiency such
as bruising due to capillary fragility were found in
early studies to be relieved by crude vitamin C extract
but not by purified Vitamin C. The bioflavinoids,
sometimes called Vitamin P, were found to be the
essential component in correcting this bruising tendency
and improving the permeability and integrity of the
capillary lining. These bioflavinoids include Hesperidin, Citrin, Rutin, Flavones,
Flavonals, Calechin, and Quercetin.
Hesperidin deficiency has been linked with abnormal
capillary leakiness as well as pain in the extremeities causing achiness, weakness,
and night leg cramps. Supplemental
hesperidin may also help reduce edema or excess swelling in the
legs due to fluid accumulation. Like other bioflavinoids, hesperidin works best when given with Vitamin C and other
bioflavinoids. No signs of toxicity have been observed with normal intake of
hesperidin.
Hesperidin is a bioflavinnoid. Bioflavonoids are any of a group of
colored substances found in many fruits, and essential
for the absorption and processing of vitamin-C. These
substances are not vitamins, per se, but, were dubbed
"vitamin P" by Dr. Albert Szent-Gyorgyi, a
famed Hungarian researcher. He is one and the same
Gyorgyi who won the Nobel Prize in Medicine for his
discovery of vitamin C. It was in the course of isolating
vitamin C that he came across the Bioflavonoids. He had a
friend with bleeding gums and thought this condition
might have something to do with a vitamin C deficiency.
He gave the man some of his raw, impure vitamin C, and
sure enough the bleeding gums cleared up.
Later on, confronted by a recurrence of bleeding gums, he
decided to try again; this time with pure vitamin C, he
expected to observe an even more dramatic result. No such
luck. The man's gums went right on bleeding. Szent-Gyorgi re-examined his earlier preparation and decided that the
effective impurity was one of the Bioflavonoids. He then
tried these by themselves, and reported that they worked.
He named these substances "vitamin P." The
Bioflavonoids thus first came into use as primarily as
protectors of capillaries, the tiniest blood vessels in
the body.
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