Multiple Myeloma is a form of cancer that is part of a range of diseases known as Plasma Cell Dyscrasia. The plasma cells are responsible for making anti-bodies against bacteria as well as foreign proteins. For unknown reasons, these cells can lose their ability to respond to signals from various immune system cells. The plasma cells then divide and start to form abnormal proteins, which damages the bone,  bone marrow, and other organs of the person's body. A sound nutritional and herbal program to help strengthen the immune system can help the person.  There is currently no known cure for the disease.

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"The person who takes medicine must recover twice, once from the disease and once from the medicine." William Osler, M.D.

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Signs and symptoms - many organs can be affected by myeloma so the symptoms and signs vary greatly. A mnemonic sometimes used to remember the common tetrad (4 parts) of multiple myeloma is CRAB: C = Calcium (elevated), R = Renal failure, A = Anemia, B = Bone lesions. Myeloma has many possible symptoms, and all symptoms may be due to other causes. They are presented here in decreasing order of incidence.

Bone Pain - myeloma bone pain usually involves the spine and ribs, and worsens with activity. Persistent localized pain may indicate a pathological bone fracture. Involvement of the vertebrae may lead to spinal cord compression. Myeloma bone disease is due to the over expression of Receptor Activator for Nuclear Factor (RANKL) by bone marrow stroma. RANKL activates the osteoclasts that resorb bone. The resulting bone lesions breakdown and are seen in plain radiographs, which may show "punched-out" lesions including the "pepper pot" appearance of the skull on radiography. The bone breakdown also releases calcium into the blood thus leading to hypercalcemia and associated symptoms.

Anemia - common with in multiple myeloma is usually normocytic and normochromic,  resulting from the replacement of the persons normal bone marrow by infiltrating tumor cells and inhibition of normal red blood cell production "hematopoiesis" by cytokines.

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Myeloma cells often collect in the bone marrow and in the outer part of bones. They may collect in only one bone and form a single mass, or tumor, called a plasmacytoma. But in most cases, the myeloma cells collect in many bones, forming many tumors and causing numerous problems. When this occurs, the disease is called multiple myeloma.

Although and multiple myeloma and plasmacytoma do affect the bones, they start in immune system cells. This type of cancer is different from bone cancer, which begins in cells that form the hard, outer part of the bone. This is important because the diagnosis and treatment of plasmacytoma and/or multiple myeloma is different from then that of bone cancer.

According to the International Myeloma Foundation, there are over 13,500 new cases of Myeloma in the United States every year, representing 20% of blood cancers, and 1% of all forms of cancer. Myeloma is more common in blacks that whites and men get it more then women. The risk of the disease increases with age. Better diagnostic techniques and the higher average age of the general population may explain the rising incidence of myeloma over the past several decades. More patients under 55 years old are being diagnosed with myeloma; risk factors include: airborne particles, atomic radiation exposure, petroleum products, pesticides, solvents, heavy metals, and industrial chemicals.

Treatment may include: Fractionated dose chemotherapy, bone marrow transplant, autologous stem cell rescue with post transplant immunotherapy, and of course nutritional and herbal supplementation.

 

 
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